Heparin decreases mesangial matrix accumulation after selective antibody-induced mesangial cell injury.
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چکیده
منابع مشابه
Steroid therapy reduces mesangial matrix accumulation in advanced IgA nephropathy.
BACKGROUND Steroid therapy for IgA nephropathy (IgAN) has been reported to ameliorate the long-term prognosis of IgAN, but its mode of action has not been fully elucidated. In this study, we examined the effect of steroids on glomerular morphological changes in IgAN. METHODS We examined 16 patients with biopsy-proven IgAN (male/female =11/5, mean age 32.1 years) who were divided into prognosi...
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Wnt/beta-catenin signaling mediates renal fibrosis in several model systems including diabetic nephropathy. Dickkopf-1 (DKK-1) is an endogenous inhibitor of Wnt/beta-catenin signaling, but whether DKK-1 modulates diabetic nephropathy is unknown. Here, we studied whether DKK-1 participates in high glucose (HG)-induced expression of profibrotic factors and renal damage. In vitro, HG increased exp...
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The mitogen-activated protein kinase (MAPK) cascade plays an important role in the regulation of various cellular functions in glomerulonephritis (GN). Here, we investigated whether extracellular signal-regulated kinase 5 (ERK5), a member of the MAPK family, is involved in the pathogenesis of chronic mesangioproliferative GN, using a rat model induced by uninephrectomy and anti-Thy-1 antibody i...
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Background: To date no specific treatment is established in mesangial proliferative glomerulonephritis in man. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cyclic GMP from GTP, can be achieved by the novel pyrazolopyridine derivative Bay 41-2272. In this study, we investigated the effects of sGC stimulation in experimental mesangial proliferative...
متن کاملStimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis.
To date, no specific treatment is established in mesangial proliferative glomerulonephritis in humans. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cGMP from GTP, can be achieved by the novel pyrazolopyridine derivative BAY 41-2272. The effect of sGC stimulation via BAY 41-2272 on mesangial proliferation was assessed in vivo using a mesangial pro...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1992
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v34921